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  • Solid-phase synthesis of a modified 13-residue seminalplasmin fragment on 1,6-hexanediol diacrylate-crosslinked polystyrene support.

Solid-phase synthesis of a modified 13-residue seminalplasmin fragment on 1,6-hexanediol diacrylate-crosslinked polystyrene support.

Peptides (2000-08-26)
C Arunan, R Nagaraj, V N Rajasekharan Pillai
ABSTRACT

A novel 1,6-hexanediol diacrylate cross-linked resin was prepared that was subsequently functionalized by using chloromethyl methyl ether to afford a high-capacity resin. The resin exhibited good swelling and its application in the successful synthesis of a 13-residue peptide corresponding to the fragment of seminalplasmin has been illustrated. The resin was chemically inert at peptide synthetic conditions.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
1,6-Hexanediol solution, BioUltra, ~6 M in H2O
Sigma-Aldrich
1,6-Hexanediol, 99%
Sigma-Aldrich
1,6-Hexanediol, 97%
Sigma-Aldrich
1,6-Hexanediol diacrylate, technical grade, 80%