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  • Cyclization reactions of homopropargyl azide derivatives catalyzed by PtCl4 in ethanol solution: synthesis of functionalized pyrrole derivatives.

Cyclization reactions of homopropargyl azide derivatives catalyzed by PtCl4 in ethanol solution: synthesis of functionalized pyrrole derivatives.

Organic letters (2006-11-03)
Kou Hiroya, Shigemitsu Matsumoto, Masayasu Ashikawa, Kentaro Ogiwara, Takao Sakamoto
ABSTRACT

[Structure: see text] PtCl4-catalyzed cyclization reactions of homopropargyl azide derivatives to pyrrole rings were investigated. Using ethanol as solvent with 2,6-di-tert-butyl-4-methylpyridine as the base was found to be the best set of conditions for effecting this ring-closing reaction. These reaction conditions can be applied to the preparation of functionalized pyrrole derivatives, with no effect on the functional groups.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Platinum(IV) chloride, ≥99.9% trace metals basis
Sigma-Aldrich
Platinum(IV) chloride, 96%
Sigma-Aldrich
2,6-Di-tert-butyl-4-methylpyridine, 98%
Sigma-Aldrich
Platinum(IV) chloride, ≥99.99% trace metals basis