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  • Chiral carboxylic acids and their effects on melting-point behaviour in co-crystals with isonicotinamide.

Chiral carboxylic acids and their effects on melting-point behaviour in co-crystals with isonicotinamide.

Acta crystallographica. Section B, Structural science (2008-11-26)
Andreas Lemmerer, Nikoletta B Báthori, Susan A Bourne
ABSTRACT

The crystal structures of co-crystals of two systems of chiral carboxylic acids, optically active and racemic 2-phenylpropionic acid and 2-phenylbutyric acid, with isonicotinamide are reported to investigate the effects of the chirality of the chiral carboxylic acids on the melting point of the co-crystal complexes. It was found that the racemic co-crystal has a higher melting point than the optically active co-crystal, which correlates with the denser packing arrangement inherent in centrosymmetric space groups.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Isonicotinamide, ReagentPlus®, 99%
Sigma-Aldrich
2-Phenylpropionic acid, 97%
Sigma-Aldrich
α-Methylhydrocinnamic acid, 98%
Sigma-Aldrich
(S)-(+)-2-Phenylpropionic acid, 97%