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  • Iron-catalysed, hydride-mediated reductive cross-coupling of vinyl halides and Grignard reagents.

Iron-catalysed, hydride-mediated reductive cross-coupling of vinyl halides and Grignard reagents.

Chemical communications (Cambridge, England) (2011-11-02)
Bryden A F Le Bailly, Mark D Greenhalgh, Stephen P Thomas
ABSTRACT

An iron-catalysed, hydride-mediated reductive cross-coupling reaction has been developed for the preparation of alkanes. Using a bench-stable iron(II) pre-catalyst, reductive cross-coupling of vinyl iodides, bromides and chlorides with aryl- and alkyl Grignard reagents successfully gave the products of formal sp(3)-sp(3) cross-coupling reactions.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Vinyl bromide, 98%
Sigma-Aldrich
Vinyl bromide solution, 1.0 M in THF