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  • Synthesis, resolution, and absolute configuration of chiral 4,4'-bipyridines.

Synthesis, resolution, and absolute configuration of chiral 4,4'-bipyridines.

The Journal of organic chemistry (2012-03-01)
Victor Mamane, Emmanuel Aubert, Paola Peluso, Sergio Cossu
ABSTRACT

A chiral polyhalogenated 4,4'-bipyridine derivative is described allowing an easy access to a new family of chiral 4,4'-bipyridines by site-selective cross-coupling reactions. The absolute configurations of all the HPLC separated enantiomers were determined by X-ray diffraction and electronic circular dichroism coupled with time-dependent density functional theory calculations.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
4,4′−Dipyridyl, 98%