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  • A facile copper-catalyzed one-pot domino synthesis of 5,12-dihydroindolo[2,1-b]quinazolines.

A facile copper-catalyzed one-pot domino synthesis of 5,12-dihydroindolo[2,1-b]quinazolines.

Organic letters (2012-03-08)
Min Jiang, Jian Li, Feng Wang, Yichao Zhao, Feng Zhao, Xiaochun Dong, Weili Zhao
ABSTRACT

A domino synthesis of 5,12-dihydroindolo[2,1-b]quinazoline derivatives via copper-catalyzed Ullmann-type intermolecular C-C and intramolecular C-N couplings is reported. Good yields of various 5,12-dihydroindolo[2,1-b]quinazoline derivatives were obtained. Reaction scopes, limitations, and the reaction mechanism are discussed.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Copper(I) iodide, purum, ≥99.5%
Sigma-Aldrich
Copper(I) iodide, 99.999% trace metals basis
Sigma-Aldrich
Copper(I) iodide, 98%