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  • Pentagalloylglucose down-regulates mast cell surface FcepsilonRI expression in vitro and in vivo.

Pentagalloylglucose down-regulates mast cell surface FcepsilonRI expression in vitro and in vivo.

FEBS letters (2009-11-12)
Natsuko Kageyama-Yahara, Yoko Suehiro, Futoshi Maeda, Shun-ichiro Kageyama, Junya Fukuoka, Tatsuo Katagiri, Takeshi Yamamoto, Makoto Kadowaki
ABSTRACT

Mast cell activation by immunoglobulin E (IgE)-mediated stimuli is a central event in the pathogenesis of allergic disorders. The present report shows that treatment with pentagalloylglucose (PGG) resulted in a down-regulation of FcepsilonRI surface expression on mucosal-type murine bone marrow-derived mast cells (mBMMCs), which correlated with a reduction in IgE-mediated activation of mBMMCs. Furthermore, PGG prevented development of allergic diarrhea in a food-allergy mouse model and suppressed the up-regulated FcepsilonRI surface expression on mast cells derived from the food-allergy mouse colon. These findings on PGG suggest its therapeutic potential for allergic diseases through suppressing the FcepsilonRI surface expression.

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Tranilast, ≥98% (HPLC), powder