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  • Urinary tartaric acid as a potential biomarker for the dietary assessment of moderate wine consumption: a randomised controlled trial.

Urinary tartaric acid as a potential biomarker for the dietary assessment of moderate wine consumption: a randomised controlled trial.

The British journal of nutrition (2014-02-11)
Jorge Regueiro, Anna Vallverdú-Queralt, Jesús Simal-Gándara, Ramón Estruch, Rosa María Lamuela-Raventós
ABSTRACT

The availability of biomarkers that allow the estimation of the intake of specific foods and dietary components, as an alternative or addition to self-reported dietary questionnaires, could greatly enhance the effectiveness of nutritional research. The aim of the present study was to assess tartaric acid, one of the major components of red and white wines, as a potential biomarker of wine consumption. A total of twenty-one healthy men participated in a randomised cross-over feeding trial. They consumed a single dose of 100, 200 or 300 ml wine at dinner. Before each intervention, the participants followed a 7 d washout period during which they avoided consuming wine or grape-based products. Morning urine was collected and analysed by liquid chromatography coupled to electrospray ionisation tandem MS. A strong significant correlation was found between wine intake and urinary tartaric acid (r(s) = 0·9220; P <0·001). Using a cut-off value of 8·84 μg/mg creatinine, tartaric acid allowed wine consumers to be differentiated from non-wine consumers. The results suggest that urinary tartaric acid may be a sensitive and specific dietary biomarker of wine consumption.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
DL-Tartaric acid, ≥99%
Sigma-Aldrich
DL-Tartaric acid, ReagentPlus®, 99%
Supelco
L-(+)-Tartaric acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Sigma-Aldrich
D-(−)-Tartaric acid, puriss., unnatural form, ≥99.0% (T)
Sigma-Aldrich
D-(−)-Tartaric acid, ReagentPlus®, 99%
Sigma-Aldrich
L-(+)-Tartaric acid, ≥99.7%, FCC, FG
Sigma-Aldrich
L-(+)-Tartaric acid, ACS reagent, ≥99.5%
Sigma-Aldrich
L-(+)-Tartaric acid, puriss. p.a., reag. ISO, 99.5-101.0% (calc. to the dried substance)
Sigma-Aldrich
L-(+)-Tartaric acid, puriss., meets analytical specification of Ph. Eur., NF, 99.7-100.5% (calc. to the dried substance), powder
Sigma-Aldrich
L-(+)-Tartaric acid, ≥99.5%
Sigma-Aldrich
L-(+)-Tartaric acid, BioXtra
Sigma-Aldrich
L-(+)-Tartaric acid, JIS special grade, ≥99.5%
Sigma-Aldrich
L-(+)-Tartaric acid, SAJ first grade, ≥99.5%
Sigma-Aldrich
L-(+)-Tartaric acid, anhydrous, free-flowing, Redi-Dri, ACS reagent, ≥99.5%
Supelco
Tartaric Acid, Pharmaceutical Secondary Standard; Certified Reference Material