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  • Iridium-catalyzed enantioselective hydrogenation of alpha,beta-unsaturated carboxylic acids.

Iridium-catalyzed enantioselective hydrogenation of alpha,beta-unsaturated carboxylic acids.

Journal of the American Chemical Society (2008-06-13)
Shen Li, Shou-Fei Zhu, Can-Ming Zhang, Song Song, Qi-Lin Zhou
ABSTRACT

A highly efficient iridium-catalyzed hydrogenation of alpha,beta-unsaturated carboxylic acids has been developed by using chiral spiro-phosphino-oxazoline ligands, affording alpha-substituted chiral carboxylic acids in exceptionally high enantioselectivities and reactivities.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
α-Methylhydrocinnamic acid, 98%