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  • Synthesis and glycosidase inhibitory activity of 1-amino-3,6-anhydro-1-deoxy-D-sorbitol derivatives.

Synthesis and glycosidase inhibitory activity of 1-amino-3,6-anhydro-1-deoxy-D-sorbitol derivatives.

Bioorganic chemistry (2010-01-12)
Stéphane Guillarme, Jean-Bernard Behr, Claudia Bello, Pierre Vogel, Christine Saluzzo
ABSTRACT

3,6-Anhydro-1-(aryl or alkylamino)-1-deoxy-D-sorbitol derivatives have been prepared in four steps from isosorbide, a by-product from the starch industry. The inhibitory activities of these new compounds have been evaluated towards 13 glycosidases. A first lead-compound was identified, which inhibited beta-N-acetylglucosaminidase from bovine kidney (82% inhibition at 1mM).

MATERIALS
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Product Description

USP
Isosorbide, United States Pharmacopeia (USP) Reference Standard