Synthesis and antibacterial properties of pyrimidine derivatives.

In this study, a series of syntheses was conducted on the pyrimidine system, obtaining bisulfite carboxyl derivatives 4 and hydroxy derivatives 5. In addition, a series of syntheses were carried out as a result of which both alkyl and aromatic amines were obtained. Then, the attempt was made to cyclize these amines in the Mannich reaction to pyrimido[4,5-d]pyrimidines 11, 12. After determination of chemical structure using physicochemical tests, also by means of crystallographic tests, all the newly obtained derivatives underwent microbiological tests on bacterial strains and fungi. The most interesting results of the microbiological tests are included later in the study.