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MiR-9 promotes microglial activation by targeting MCPIP1.

Nature communications (2014-07-16)
Honghong Yao, Rong Ma, Lu Yang, Guoku Hu, Xufeng Chen, Ming Duan, Yeonhee Kook, Fang Niu, Ke Liao, Minggui Fu, Gang Hu, Pappachan Kolattukudy, Shilpa Buch
ABSTRACT

Microglia participate in innate inflammatory responses within the central nervous system. The highly conserved microRNA-9 (miR-9) plays critical roles in neurogenesis as well as axonal extension. Its role in microglial inflammatory responses, however, remains poorly understood. Here we identify a unique role of miR-9 in mediating the microglial inflammatory response via distinct signalling pathways. MiR-9-mediated regulation of cellular activation involved downregulated expression of the target protein, monocyte chemotactic protein-induced protein 1 (MCPIP1) that is crucial for controlling inflammation. Results indicate that miR-9-mediated cellular activation involved signalling via the NF-κB pathway, but not the β-catenin pathway.

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