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  • Satellite cell activation and mTOR signaling pathway response to resistance and combined exercise in elite weight lifters.

Satellite cell activation and mTOR signaling pathway response to resistance and combined exercise in elite weight lifters.

European journal of applied physiology (2017-09-25)
Chang Hyun Lim, Thien Suong Luu, Le Quy Phoung, Tae Seok Jeong, Chang Keun Kim
ABSTRACT

Our aim was to compare the effects of a single exercise training mode (resistance exercise) with a combined exercise training (resistance and plyometric exercise) mode on satellite cell activity and anabolic signaling at the molecular level. Eighteen male weight lifters (20 ± 4 years, BMI 27 ± 6 kg/m Exercise induced increases in satellite cell activation and myofibrillar protein synthesis following both exercise modes, but the resistance exercise group was superior compared to the combined exercise group in satellite cell activity expressed by Ki67/CD56 (165 vs 232%) and PI3K/Akt protein expression (121 vs 157%), mTOR protein expression (117 vs 288%), p70S6K protein expression (253 vs 809%), and 4E-BP1 protein expression (70 vs 139%) of anabolic signaling pathway. These results suggest that the previous findings showing a greater effect of combined as opposed to a single exercise mode could be the effect of a greater training volume rather than a true-training effect of a combined exercise program.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Anti-Laminin antibody produced in rabbit, 0.5 mg/mL, affinity isolated antibody, buffered aqueous solution
Sigma-Aldrich
Donkey serum