MilliporeSigma
  • SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.

eLife (2017-10-25)
Sung Jun Bae, Lisheng Ni, Adam Osinski, Diana R Tomchick, Chad A Brautigam, Xuelian Luo
ABSTRACT

The Hippo pathway controls tissue growth and homeostasis through a central MST-LATS kinase cascade. The scaffold protein SAV1 promotes the activation of this kinase cascade, but the molecular mechanisms remain unknown. Here, we discover SAV1-mediated inhibition of the PP2A complex STRIPAK

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Monoclonal ANTI-FLAG® M2 antibody produced in mouse, 1 mg/mL, clone M2, affinity isolated antibody, buffered aqueous solution (50% glycerol, 10 mM sodium phosphate, and 150 mM NaCl, pH 7.4)
Sigma-Aldrich
Monoclonal Anti-Pan Cadherin antibody produced in mouse, clone CH-19, ascites fluid