CDK2AP1
cyclin-dependent kinase 2 associated protein 1
Synonyms:
DOC1, DORC1, ST19, doc-1, p12DOC-1
Species:
Human CDK2AP1 (8099), Mouse Cdk2ap1 (13445), Rat Cdk2ap1 (360804), domestic cat CDK2AP1 (101089721), domestic guinea pig Cdk2ap1 (100734683), sheep CDK2AP1 (101122554), naked mole-rat Cdk2ap1 (101723683), dog CDK2AP1 (477452), chicken CDK2AP1 (416826), cow CDK2AP1 (615387)
UniProtKB ID:
Gene ID:
- Human(8099) Summary: The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
- Mouse(13445) CDK2 (cyclin-dependent kinase 2)-associated protein 1
- Rat(360804) cyclin-dependent kinase 2 associated protein 1
- domestic cat(101089721) cyclin-dependent kinase 2 associated protein 1
- domestic guinea pig(100734683) cyclin-dependent kinase 2 associated protein 1
- sheep(101122554) cyclin-dependent kinase 2 associated protein 1
- naked mole-rat(101723683) cyclin-dependent kinase 2 associated protein 1
- dog(477452) cyclin-dependent kinase 2 associated protein 1
- chicken(416826) cyclin-dependent kinase 2 associated protein 1
- cow(615387) cyclin-dependent kinase 2 associated protein 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-cdk2 Antibody, Upstate®, from rabbit,
Species Reactivity
human
Application
immunoprecipitation (IP)
western blot
western blot
Anti-CDK2AP1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-CDK2AP1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-CDK2AP1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
esiRNA
Product Number
Description
Species