CDKN2B
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Synonyms:
CDK4I, INK4B, MTS2, P15, TP15, p15INK4b
Species:
Human CDKN2B (1030), Mouse Cdkn2b (12579), Rat Cdkn2b (25164), Horse CDKN2B (100034122), dog CDKN2B (481563), chicken CDKN2B (395076), domestic guinea pig Cdkn2b (100732246), sheep CDKN2B (101107164), cow CDKN2B (527124), domestic cat CDKN2B (101087014)
UniProtKB ID:
Gene ID:
- Human(1030) Summary: This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
- Mouse(12579) cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
- Rat(25164) cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
- Horse(100034122) cyclin-dependent kinase 2B inhibitor
- dog(481563) cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
- chicken(395076) cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
- domestic guinea pig(100732246) cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
- sheep(101107164) cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
- cow(527124) cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
- domestic cat(101087014) cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CDKN2B antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-p15 INK antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-CDKN2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-p15 Antibody, clone PAT56B, clone PAT56B, from rat,
Species Reactivity
mouse
Application
immunohistochemistry
western blot
western blot
Anti-INK4b (p15) Antibody, clone GF10 (10C7A6), culture supernatant, clone GF10 (10C7A6), from mouse,
Species Reactivity
human
Application
western blot
Small Molecule - Inhibitor
Kits
Product Number
Description
Species
CpG WIZ™ p15 -Methylation specific PCR assay, The CpG WIZ p15 Amplification Kit is used for determining the methylation status of the p15 promoter by methylation-specific PCR (MSP).,
Species
human
esiRNA
Product Number
Description
Species