DFFB
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
Synonyms:
CAD, CPAN, DFF-40, DFF2, DFF40
Species:
Human DFFB (1677), Mouse Dffb (13368), Rat Dffb (84359), Zebrafish dffb (373130), dog DFFB (489623), domestic cat DFFB (101092127), cow DFFB (512730), sheep DFFB (101101905), domestic guinea pig Dffb (100713108), naked mole-rat Dffb (101713910)
UniProtKB ID:
Gene ID:
- Human(1677) Summary: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined. [provided by RefSeq, Jul 2008]
- Mouse(13368) DNA fragmentation factor, beta subunit
- Rat(84359) DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
- Zebrafish(373130) DNA fragmentation factor, beta polypeptide (caspase-activated DNase)
- dog(489623) DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
- domestic cat(101092127) DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
- cow(512730) DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
- sheep(101101905) DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
- domestic guinea pig(100713108) DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
- naked mole-rat(101713910) DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
- chicken(374158) DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-DFFB antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
western blot
Anti-DFFB antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-DFF40 Antibody, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-DFF40 (ab3) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunocytochemistry
western blot
immunocytochemistry
western blot
Anti-ICAD/DFF Antibody, NT (a.a. 2-21 of mouse ICAD), Chemicon®, from rabbit,
Species Reactivity
mouse
Application
western blot