DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
Synonyms:
ICF, ICF1, M.HsaIIIB
Species:
Human DNMT3B (1789), Mouse Dnmt3b (13436), Rat Dnmt3b (444985), domestic guinea pig Dnmt3b (100731772), naked mole-rat Dnmt3b (101725788), dog DNMT3B (100685634), Horse DNMT3B (100053900), domestic cat DNMT3B (101092926), cow DNMT3B (353354), Domestic Rabbit DNMT3B (100349823) ...More
UniProtKB ID:
Gene ID:
- Human(1789) Summary: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]
- Mouse(13436) DNA methyltransferase 3B
- Rat(444985) DNA (cytosine-5-)-methyltransferase 3 beta
- domestic guinea pig(100731772) DNA (cytosine-5-)-methyltransferase 3 beta
- naked mole-rat(101725788) DNA (cytosine-5-)-methyltransferase 3 beta
- dog(100685634) DNA (cytosine-5-)-methyltransferase 3 beta
- Horse(100053900) DNA (cytosine-5-)-methyltransferase 3 beta
- domestic cat(101092926) DNA (cytosine-5-)-methyltransferase 3 beta
- cow(353354) DNA (cytosine-5-)-methyltransferase 3 beta
- Domestic Rabbit(100349823) DNA (cytosine-5-)-methyltransferase 3 beta
- sheep(100500777) DNA (cytosine-5-)-methyltransferase 3 beta
- Zebrafish(321084) DNA (cytosine-5-)-methyltransferase 3 beta
- chicken(419287) DNA (cytosine-5-)-methyltransferase 3 beta
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Dnmt3b Antibody, clone D3B2-2C1, clone D3B2-2C1, from rat,
Species Reactivity
human
Application
immunoprecipitation (IP)
western blot
western blot
Anti-DNMT3B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-DNMT3B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-DNMT3B Antibody, clone 2N12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, monkey
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-DNMT3B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Proteins
Product Number
Description
Species
DNMT3B/DNMT3L Active human, recombinant, expressed in baculovirus infected insect cells, ≥90% (SDS-PAGE),
Species
human
esiRNA
Product Number
Description
Species