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GCLM

glutamate-cysteine ligase, modifier subunit

Synonyms:
GLCLR
Species:
UniProtKB ID:
Gene ID:
  • Human(2730) Summary: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq, Jul 2008]
  • Mouse(14630) glutamate-cysteine ligase, modifier subunit
  • Rat(29739) glutamate cysteine ligase, modifier subunit
  • dog(612283) glutamate-cysteine ligase, modifier subunit
  • domestic guinea pig(100725164) glutamate-cysteine ligase, modifier subunit
  • domestic cat(101081562) glutamate-cysteine ligase, modifier subunit
  • fruit fly(248194) Glutamate-cysteine ligase modifier subunit
  • chicken(424492) glutamate-cysteine ligase, modifier subunit
  • naked mole-rat(101703324) glutamate-cysteine ligase, modifier subunit
  • sheep(101117899) glutamate-cysteine ligase, modifier subunit
  • Zebrafish(333974) glutamate-cysteine ligase, modifier subunit
  • cow(525659) glutamate-cysteine ligase, modifier subunit

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-GCLM antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-GCLM antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-GCLM antibody produced in rabbit, ,
Species Reactivity
Application
western blot
Anti-GCLM antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
Anti-GCLM antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
L-Buthionine-sulfoximine, ≥97% (TLC),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Gclm,
Species
mouse
MISSION® esiRNA, targeting human GCLM,
Species
human