GNRHR
gonadotropin-releasing hormone receptor
Synonyms:
GNRHR1, GRHR, HH7, LHRHR, LRHR
Species:
Human GNRHR (2798), Mouse Gnrhr (14715), Rat Gnrhr (81668), domestic cat GNRHR (101088838), chicken GNRHR (427517), dog GNRHR (403718), Domestic Rabbit GNRHR (100009509), naked mole-rat Gnrhr (101704341), domestic guinea pig Gnrhr (100135532), Horse GNRHR (100033874)
UniProtKB ID:
Gene ID:
- Human(2798) Summary: This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008]
- Mouse(14715) gonadotropin releasing hormone receptor
- Rat(81668) gonadotropin releasing hormone receptor
- domestic cat(101088838) gonadotropin-releasing hormone receptor
- chicken(427517) gonadotropin-releasing hormone receptor
- dog(403718) gonadotropin-releasing hormone receptor
- Domestic Rabbit(100009509) gonadotropin-releasing hormone receptor
- naked mole-rat(101704341) gonadotropin-releasing hormone receptor
- domestic guinea pig(100135532) gonadotropin releasing hormone receptor
- Horse(100033874) gonadotropin-releasing hormone receptor
- cow(281798) gonadotropin-releasing hormone receptor
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Small Molecule - Agonist
Product Number
Description
Species
Goserelin for NMR identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Small Molecule - Antagonist
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-GnRH-R Antibody, clone F1G4, clone FIG4, from mouse,
Species Reactivity
human
Application
ELISA
dot blot
flow cytometry
immunohistochemistry
western blot
dot blot
flow cytometry
immunohistochemistry
western blot
Anti-GNRHR antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
immunofluorescence
Anti-GRHR/LRHR antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human
Application
ELISA
western blot
western blot
Anti-GNRHR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Proteins
Product Number
Description
Species
[des-Gly10, D-Ala6]-LH-RH ethylamide acetate salt hydrate, ≥97% (HPLC), powder,
Species
mouse, human
esiRNA
Product Number
Description
Species