MLH1
mutL homolog 1
Synonyms:
COCA2, FCC2, HNPCC, HNPCC2, hMLH1
Species:
Human MLH1 (4292), Mouse Mlh1 (17350), Rat Mlh1 (81685), Thale Cress MLH1 (826493), fruit fly Mlh1 (35796), sheep MLH1 (101108344), domestic guinea pig Mlh1 (100717848), naked mole-rat Mlh1 (101698546), Domestic Rabbit MLH1 (100337912), Horse MLH1 (100050351) ...More
UniProtKB ID:
Gene ID:
- Human(4292) Summary: This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009]
- Mouse(17350) mutL homolog 1 (E. coli)
- Rat(81685) mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
- Thale Cress(826493) DNA mismatch repair protein MLH1
- fruit fly(35796) CG11482 gene product from transcript CG11482-RB
- sheep(101108344) mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
- domestic guinea pig(100717848) mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
- naked mole-rat(101698546) mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
- Domestic Rabbit(100337912) mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
- Horse(100050351) mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
- cow(533652) mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
- dog(477019) mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
- domestic cat(101089037) mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
- Zebrafish(393632) mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
- chicken(420729) mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-MLH1 antibody produced in mouse, clone M1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
proximity ligation assay
western blot
immunofluorescence
immunohistochemistry
proximity ligation assay
western blot
Monoclonal Anti-MLH1 antibody produced in mouse, clone 4C9C7, ascites fluid,
Species Reactivity
human, monkey
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-MLH1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry