MPL
myeloproliferative leukemia virus oncogene
Synonyms:
C-MPL, CD110, MPLV, THCYT2, TPOR
Species:
Human MPL (4352), Mouse Mpl (17480), Rat Mpl (366455), chicken MPL (414804), Zebrafish mpl (445381), domestic cat MPL (101097002), dog MPL (610801), Horse MPL (100066544), cow MPL (528492), Domestic Rabbit MPL (100008643) ...More
UniProtKB ID:
Gene ID:
- Human(4352) Summary: In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]
- Mouse(17480) myeloproliferative leukemia virus oncogene
- Rat(366455) myeloproliferative leukemia virus oncogene
- chicken(414804) myeloproliferative leukemia virus oncogene
- Zebrafish(445381) myeloproliferative leukemia virus oncogene
- domestic cat(101097002) myeloproliferative leukemia virus oncogene
- dog(610801) myeloproliferative leukemia virus oncogene
- Horse(100066544) myeloproliferative leukemia virus oncogene
- cow(528492) myeloproliferative leukemia virus oncogene
- Domestic Rabbit(100008643) myeloproliferative leukemia virus oncogene
- sheep(101110279) myeloproliferative leukemia virus oncogene
- naked mole-rat(101707597) myeloproliferative leukemia virus oncogene
- domestic guinea pig(100718268) myeloproliferative leukemia virus oncogene
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Small Molecule - Agonist
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MPL antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry
western blot
western blot
Anti-TPO-R/CD110/c-Mpl Antibody, clone 5Q9Z6, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
western blot
Anti-TPOR/c-Mpl Antibody, Upstate®, from rabbit,
Species Reactivity
human, mouse
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot