NRG3
neuregulin 3
Synonyms:
HRG3, pro-NRG3
Species:
Human NRG3 (10718), Mouse Nrg3 (18183), Rat Nrg3 (498596), dog NRG3 (479263), Horse NRG3 (100065480), naked mole-rat Nrg3 (101709491), domestic guinea pig Nrg3 (100726543), chicken NRG3 (428937), Domestic Rabbit NRG3 (100337933), sheep NRG3 (101112537) ...More
UniProtKB ID:
Gene ID:
- Human(10718) Summary: This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]
- Mouse(18183) neuregulin 3
- Rat(498596) neuregulin 3
- dog(479263) neuregulin 3
- Horse(100065480) neuregulin 3
- naked mole-rat(101709491) neuregulin 3
- domestic guinea pig(100726543) neuregulin 3
- chicken(428937) neuregulin 3
- Domestic Rabbit(100337933) neuregulin 3
- sheep(101112537) neuregulin 3
- domestic cat(101082012) neuregulin 3
- cow(539977) neuregulin 3
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-NRG3 (C-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
Anti-Neuregulin 3 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
western blot
western blot
Anti-Neuregulin-3 (NRG3) Antibody, clone 6V9X1, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
western blot
esiRNA
Product Number
Description
Species