PTGIS
prostaglandin I2 (prostacyclin) synthase
Synonyms:
CYP8, CYP8A1, PGIS, PTGI
Species:
Human PTGIS (5740), Mouse Ptgis (19223), Rat Ptgis (25527), dog PTGIS (485919), Goat PTGIS (100860894), cow PTGIS (282021), domestic guinea pig Ptgis (100734621), Zebrafish ptgis (559148), sheep PTGIS (101116418), Horse PTGIS (100071412) ...More
UniProtKB ID:
Gene ID:
- Human(5740) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
- Mouse(19223) prostaglandin I2 (prostacyclin) synthase
- Rat(25527) prostaglandin I2 (prostacyclin) synthase
- dog(485919) prostaglandin I2 (prostacyclin) synthase
- Goat(100860894) prostaglandin I2 (prostacyclin) synthase
- cow(282021) prostaglandin I2 (prostacyclin) synthase
- domestic guinea pig(100734621) prostaglandin I2 (prostacyclin) synthase
- Zebrafish(559148) prostaglandin I2 (prostacyclin) synthase
- sheep(101116418) prostaglandin I2 (prostacyclin) synthase
- Horse(100071412) prostaglandin I2 (prostacyclin) synthase
- naked mole-rat(101700601) prostaglandin I2 (prostacyclin) synthase
- domestic cat(101082050) prostaglandin I2 (prostacyclin) synthase
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PTGIS antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, human, mouse, rat
Application
western blot
Anti-PTGIS antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-PTGIS antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-PTGIS antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Monoclonal Anti-PTGIS, (C-terminal) antibody produced in mouse, clone 3B11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Small Molecule - Ligand
Product Number
Description
Species