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30681

Sigma-Aldrich

L-4-Hydroxyproline methyl ester hydrochloride

≥98.0% (GC)

Synonym(s):

(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid methyl ester hydrochloride, trans-4-Hydroxyproline methyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C6H11NO3 · HCl
CAS Number:
40216-83-9
Molecular Weight:
181.62
Beilstein:
4716932
MDL number:
MFCD00080855
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
57648453
NACRES:
NA.22

Assay

≥98.0% (GC)

form

solid

reaction suitability

reaction type: solution phase peptide synthesis

application(s)

peptide synthesis

SMILES string

Cl.COC(=O)[C@@H]1C[C@@H](O)CN1

InChI

1S/C6H11NO3.ClH/c1-10-6(9)5-2-4(8)3-7-5;/h4-5,7-8H,2-3H2,1H3;1H/t4-,5+;/m1./s1

InChI key

KLGSHNXEUZOKHH-JBUOLDKXSA-N

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Emily M Christensen et al.
The Journal of biological chemistry, 295(52), 18316-18327 (2020-10-29)
Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Δ1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. Many cancers alter their proline metabolism by up-regulating the proline cycle and proline biosynthesis, and knockdowns of

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