902691

Hydroxy-PEG5-t-butyl ester

• Synonym(s): tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate, HO-PEG5-CO-OtBu
• Empirical Formula (Hill Notation): C₁₇H₃₄O₈
• CAS Number: 850090-09-4
• Molecular Weight: 366.45
• MDL number: MFCD20926402
• UNSPSC Code: 51171641

Properties

• Assay: ≥95%
• form: liquid
• reaction suitability: reagent type: cross-linking reagent
• refractive index: n/D 1.448
• density: 1.071
• functional group: ester; hydroxyl
• storage temp.: −20°C
• SMILES string: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCO

Description

Application

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Other Notes

Synthesis and Application of Poly(phenylene Ethynylene)s for Bioconjugation: A Conjugated Polymer-Based Fluorogenic Probe for Proteases

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable