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860510P

Avanti

C10 Ceramide (d18:1/10:0)

Avanti Research™ - A Croda Brand 860510P, powder

Synonym(s):

N-decanoyl-D-erythro-sphingosine

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About This Item

Empirical Formula (Hill Notation):
C28H55NO3
CAS Number:
111122-57-7
Molecular Weight:
453.74
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 5 mg (860510P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860510P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC[C@]([H])(NC(CCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC

InChI

1S/C28H55NO3/c1-3-5-7-9-11-12-13-14-15-16-18-19-21-23-27(31)26(25-30)29-28(32)24-22-20-17-10-8-6-4-2/h21,23,26-27,30-31H,3-20,22,24-25H2,1-2H3,(H,29,32)/b23-21+/t26-,27+/m0/s1

InChI key

FDWVAQFAMZLCAX-NBNLIBPQSA-N

General description

C10 Ceramide (d18:1/10:0) is a synthetic ceramide containing sphingosine with decanoic acid. It has a short acyl chain length than sphingosine acyl chain.

Application

C10 Ceramide (d18:1/10:0) or N-decanoyl-D-erythro-sphingosine has been used:
  • as an internal standard in galactocerebrosidase (GALC) assay
  • to study its role on the physical properties of edible organogels and on their ability to induce cell death of various cancer cell lines
  • to study its mixing behavior with other ceramides having the same sphingosine base but varying N-linked acyl chain length

Biochem/physiol Actions

Ceramides modulate stress responses and inflammation. It also controls cell differentiation, proliferation and apoptosis.

Packaging

5 mL Amber Glass Screw Cap Vial (860510P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Joseph J Orsini et al.
Clinical biochemistry, 42(9), 877-884 (2009-03-26)
The aim of this study was to develop a newborn screening algorithm for Krabbe disease. We measured the galactocerebrosidase activity of 139,074 anonymous newborns, 56 known carriers, and 16 Krabbe patients using a tandem mass spectrometry method. The activities were
Meenu N Perera et al.
Chemistry and physics of lipids, 194, 110-116 (2015-09-27)
A ceramide commonly found in mammalian cells, C16-ceramide (N-palmitoyl-d-erythro-sphingosine), is capable of forming large, protein-permeable channels in the mitochondrial outer membrane (MOM). However, C16-ceramide is unable to permeabilize the plasma membrane of erythrocytes. This specificity is unexpected considering that ceramide
Michael A Rogers et al.
Food science & nutrition, 5(3), 579-587 (2017-06-03)
Short-chain ceramides, such as N-acetoyl-d-erythro-sphingosine (C2), have a remarkable ability to structure edible oils, such as canola oil, into self-standing organogels without any added saturated or trans fats. These short-chain ceramides are ubiquitously found in foods ranging from eggs to
Fernando Dupuy et al.
Chemistry and physics of lipids, 165(6), 615-629 (2012-07-12)
The organization of lipids within membranes strongly depends on the interaction with other lipid and protein molecules. Sphingolipids comprise a structurally diverse family, the ceramides being some of the simplest members. Although small chemical modifications of ceramide structure, such as
Dimple Kauhanen et al.
Analytical and bioanalytical chemistry, 408(13), 3475-3483 (2016-02-29)
Monitoring the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios thereof in human plasma empowers the prediction of fatal outcome of coronary artery disease (CAD). We describe a validated liquid chromatography-tandem mass spectrometry
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