999998P
Avanti
06:0 Diether PC
Avanti Research™ - A Croda Brand 999998P, powder
Synonym(s):
1,2-di-O-hexyl-sn-glycero-3-phosphocholine
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About This Item
Empirical Formula (Hill Notation):
C20H44NO6P
CAS Number:
Molecular Weight:
425.54
UNSPSC Code:
51191904
NACRES:
NA.25
Recommended Products
form
powder
packaging
pkg of 1 × 10 mg (999998P-10mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 999998P
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OCCCCCC)COCCCCCC)=O
General description
06:0 Diether PC (phosphocholine) is a glycerophospholipid having two hexane chains attached to the sn-1 and sn-2 positions of the glycerol backbone by ether bonds. It has choline as the alcohol moiety, attached to the phosphate group.
Application
06:0 Diether PC or 1,2-di-O-hexyl-sn-glycero-3-phosphocholine might be used:
- in bicelle media to measure the H—C one-bond residual dipolar couplings for trisaccharides, Lewis X (Lex) and Lewis A (Lea) methyl glycosides using nuclear magnetic resonance (NMR) residual dipolar couplings
- to compose isotropically tumbling small bicelles, to study its size and morphology by 31P NMR and atomic force microscopy (AFM)
- in bicelle preparation for NMR studies
Biochem/physiol Actions
06:0 Diether PC (phosphocholine) is useful for bicelles preparation. Bicelles can be integrated into standard crystallization protocols and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Incorporating 06:0 Diether PC in bicelles results in bicelles similar to conventional phospholipid bicelles but with improved chemical stability.
Packaging
5 mL Clear Glass Sealed Ampule (999998P-10mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
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Hongwei Wu et al.
Biochimica et biophysica acta, 1798(3), 482-488 (2009-11-17)
Aqueous phospholipid mixtures that form bilayered micelles (bicelles) have gained wide use by molecular biophysicists during the past 20 years for spectroscopic studies of membrane-bound peptides and structural refinement of soluble protein structures. Nonetheless, the utility of bicelle systems may
Hugo F Azurmendi et al.
Biopolymers, 63(2), 89-98 (2002-01-12)
The conformations of the histo-blood group carbohydrate antigens Lewis X (Le(x)) and Lewis A (Le(a)) were studied by NMR measurements of one-bond C-H residual dipolar couplings in partially oriented liquid crystal solutions. A strategy for rapid calculation of the difference
Mohamed N Triba et al.
European biophysics journal : EBJ, 35(3), 268-275 (2005-09-28)
A protocol is described for the reconstitution of a transmembrane beta-barrel protein domain, tOmpA, into lipid bicelles. tOmpA is the largest protein to be reconstituted in bicelles to date. Its insertion does not prevent bicelles from orienting with their plane
John M Dean et al.
Protein & cell, 9(2), 196-206 (2017-05-20)
Ether lipids, such as plasmalogens, are peroxisome-derived glycerophospholipids in which the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond, as opposed to an ester bond in the more common diacyl phospholipids. This
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