D-145

N-Desmethylclobazam solution

1.0 mg/mL (acetonitrile:DMSO (90:10 v/v)), ampule of 1 mL, certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₁₅H₁₁ClN₂O₂
• CAS Number: 22316-55-8
• Molecular Weight: 286.71
• MDL number: MFCD00871860
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 1.0 mg/mL (acetonitrile:DMSO (90:10 v/v))
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• InChI: 1S/C15H11ClN2O2/c16-10-6-7-12-13(8-10)18(11-4-2-1-3-5-11)15(20)9-14(19)17-12/h1-8H,9H2,(H,17,19)
• InChI key: RRTVVRIFVKKTJK-UHFFFAOYSA-N

Description

General description

Ephedrine is a methamphetamine analog commonly used as a stimulant and appetite suppressant. It is also found as an active constituent in herbs used for traditional Chinese medicine, such as má huáng. This certified reference standard can be used Snap-N-Spike^® as a starting material in the preparation of calibrators or controls for clinical or forensic applications or Snap-N-Shoot^® in quality control testing of dietary supplements containing ephedrine.

Application

• N-Desmethylclobazam metabolite research applications: N-Desmethylclobazam is a critical metabolite in the pharmacokinetic studies of clobazam, used for understanding its biotransformation and elimination patterns in the body. This knowledge is vital for optimizing dosing regimens in clinical settings, particularly for treating conditions like epilepsy (Tomasini et al., 1985).


• Clobazam impurity profiling in pharmaceutical analysis: The analysis of N-Desmethylclobazam is essential in impurity profiling where it serves as a marker for the purity and stability of clobazam formulations. This application is crucial in regulatory compliance and quality control of pharmaceutical products (Kunicki, 2001).


• N-Desmethylclobazam reference standard for bioanalytical method development: Used extensively as a reference standard in the development of bioanalytical methods, N-Desmethylclobazam enables accurate and reliable quantification of clobazam and its metabolites in biological samples, supporting clinical and forensic investigations (Levy et al., 1983).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H302 + H312 + H332,H319
• Precautionary Statements: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 35.6 °F - closed cup
• Flash Point(C): 2.0 °C - closed cup