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Key Documents

04-039

Sigma-Aldrich

Anti-20S proteasome subunit α2 Antibody, clone MCP21

clone MCP21, Upstate®, from mouse

Synonym(s):

HC3, proteasome subunit alpha type 2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.28

biological source

mouse

Quality Level

100

antibody form

ascites fluid

antibody product type

primary antibodies

clone

MCP21, monoclonal

species reactivity

human, rabbit, bovine

manufacturer/tradename

Upstate®

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_002787.3

UniProt accession no.

P25787

shipped in

dry ice

Gene Information

bovine ... Psma2(539141)
human ... PSMA2(5683)
rabbit ... Psma2(100355295)

Specificity

Recognizes proteasome subunit alpha type 2.

Immunogen

Human placenta derived proteasomes

Application

Anti-20S proteasome subunit α2 Antibody, clone MCP21 detects level of 20S proteasome subunit α2 & has been published & validated for use in IP, WB, IH.
Research Category
Protein Trafficking
Research Sub Category
Ubiquitin & Ubiquitin Metabolism

Target description

26 kDa

Physical form

100 µL concentration of 1mg/mL purified ascites in PBS containing 0.01M sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
Ascites
Format: Purified

Storage and Stability

Stable for 1 year at -20°C from date of shipment for up to 12 months.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Tomasz Klaus et al.
Scientific reports, 6, 30938-30938 (2016-08-04)
Mouse immunoglobulins M (IgMs) that recognize human blood group antigens induce haemagglutination and are used worldwide for diagnostic blood typing. Contrary to the current belief that IgGs are too small to simultaneously bind antigens on two different erythrocytes, we obtained
G Zhong et al.
The Journal of experimental medicine, 191(9), 1525-1534 (2000-05-03)
We have previously shown that the obligate intracellular pathogen chlamydia can suppress interferon (IFN)-gamma-inducible major histocompatibility complex (MHC) class II expression in infected cells by degrading upstream stimulation factor (USF)-1. We now report that chlamydia can also inhibit both constitutive
Impact of ageing on proteasome structure and function in human lymphocytes
Carrard, Geraldine, et al
The International Journal of Biochemistry & Cell Biology, 35, 728-739 (2003)
K B Hendil et al.
The Biochemical journal, 305 ( Pt 1), 245-252 (1995-01-01)
The proteasome or multicatalytic endopeptidase from eukaryotic cells consists of at least 14 subunits that fall into two families, alpha and beta. Subunit-specific monoclonal antibodies against ten different subunits of human proteasomes have been produced, together with an antibody that
Tomasz Klaus et al.
Frontiers in immunology, 9, 1096-1096 (2018-06-08)
Mouse IgG3 is highly protective against several life-threatening bacteria. This isotype is the only one among mouse IgGs that forms non-covalent oligomers, has increased functional affinity to polyvalent antigens, and efficiently agglutinates erythrocytes. IgG3 also triggers the complement cascade. The

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