Skip to Content
MilliporeSigma
All Photos(1)

Documents

539470

Sigma-Aldrich

Proteinase K Inhibitor

Proteinase K Inhibitor is a tetrapeptidyl chloromethyl ketone compound that acts as an active-site-targeting irreversible inhibitor against proteinase K.

Synonym(s):

Proteinase K Inhibitor, MeOSuc-AAPF-CMK

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C26H35ClN4O7
Molecular Weight:
551.03
UNSPSC Code:
12352202
NACRES:
NA.54

Quality Level

Assay

≥97% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

solubility

DMSO: 3 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A tetrapeptidyl chloromethyl ketone compound that acts as an active-site-targeting irreversible inhibitor against proteinase K (Cat. Nos. 539480, 70663, & 71049). Shown to be more potent than MeOSuc-AAPV-CMK (Cat. Nos. 324745) in preventing the degradation of reverse transcriptase and albumin by proteinase K.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

MeOSuc-Ala-Ala-Pro-Phe-CH₂Cl

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at -20°C.

Other Notes

Kore, A.R., et al. 2009. Bioorg. Med. Chem. Lett.19, 1296.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Darci Phillips et al.
Nature communications, 12(1), 6726-6726 (2021-11-20)
Cutaneous T cell lymphomas (CTCL) are rare but aggressive cancers without effective treatments. While a subset of patients derive benefit from PD-1 blockade, there is a critically unmet need for predictive biomarkers of response. Herein, we perform CODEX multiplexed tissue
Julia Joung et al.
Nature communications, 13(1), 1606-1606 (2022-03-27)
The cellular processes that govern tumor resistance to immunotherapy remain poorly understood. To gain insight into these processes, here we perform a genome-scale CRISPR activation screen for genes that enable human melanoma cells to evade cytotoxic T cell killing. Overexpression

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service