681625

W-5, Hydrochloride

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 230 µM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 240 µM).

• Synonym(s): W-5, Hydrochloride, N-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl
• Empirical Formula (Hill Notation): C₁₆H₂₂N₂O₂S · xHCl
• CAS Number: 61714-25-8
• Molecular Weight: 306.42 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (NMR)
• form: crystalline solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• solubility: DMSO: soluble; water: soluble
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C16H22N2O2S.ClH/c17-12-5-1-2-6-13-18-21(19,20)16-11-7-9-14-8-3-4-10-15(14)16;/h3-4,7-11,18H,1-2,5-6,12-13,17H2;1H
• InChI key: HOCSVIGHWPLMFC-UHFFFAOYSA-N

Description

General description

A cell-permeable and reversible calmodulin antagonist that inhibits Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 240 µM) and myosin light chain kinase (IC₅₀ = 230 µM).

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 230 µM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 240 µM).

Biochem/physiol Actions

Cell permeable: yes

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 230 &microM and 240 µM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.

Warning

Toxicity: Standard Handling (A)

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable