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Key Documents

AB1745

Sigma-Aldrich

Anti-Connexin 45 Antibody, near CT, cytoplasmic

Chemicon®, from rabbit

Synonym(s):

Cx45

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, human, mouse

species reactivity (predicted by homology)

dog (based on 100% sequence homology)

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

UniProt accession no.

P36383

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

dog ... Gjc1(490936)
human ... GJC1(10052)
mouse ... Gjc1(14615)
rat ... Gjc1(266706)

Specificity

Recognizes Human, rat and mouse Connexin 45. Due to sequence homologies, this antibody is also expected to react with canine (100% homology) Connexin 45. Other species not tested.

Immunogen

KLH-conjugated synthetic, linear peptide corresponding to human Connexin 45 near the C-terminus.

Application

Detect Connexin 45 using this Anti-Connexin 45 Antibody, near C-terminus, cytoplasmic validated for use in IP, WB, IH.

Physical form

Format: Purified

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M Nitta et al.
Journal of animal science, 88(10), 3269-3279 (2010-06-22)
During mammalian oogenesis, intercellular communication between oocytes and the surrounding follicle cells through gap junction channels is crucial for oocyte development and maturation. The channel properties of gap junctions may be affected by the composition or combination of connexins, the
Erika R Kinjo et al.
PloS one, 9(10), e109149-e109149 (2014-10-10)
Gap junction (GJ) channels have been recognized as an important mechanism for synchronizing neuronal networks. Herein, we investigated the participation of GJ channels in the pilocarpine-induced status epilepticus (SE) by analyzing electrophysiological activity following the blockade of connexins (Cx)-mediated communication.
Loïc Le Gal et al.
Journal of the American Heart Association, 8(8), e010823-e010823 (2019-04-05)
Background Gap junction channels made of Connexin37 (Cx37) are expressed by aortic endothelial and smooth muscle cells of hypertensive mice, as well as by the renin-secreting cells of kidneys. Methods and Results To decipher whether Cx37 has any role in
Karen Maass et al.
Circulation research, 101(12), 1283-1291 (2007-10-13)
Haplodeficient mice expressing carboxyl-terminally truncated Cx43 (K258stop/KO), instead of the wild-type Cx43 isoform, reach adulthood and reveal no abnormalities in heart morphology. Here, we have analyzed the expression of K258stop protein and the morphology of gap junctions in adult hearts
Junichi Sugita et al.
Nature communications, 12(1), 1910-1910 (2021-03-28)
Cardiac arrhythmias are a primary contributor to sudden cardiac death, a major unmet medical need. Because right ventricular (RV) dysfunction increases the risk for sudden cardiac death, we examined responses to RV stress in mice. Among immune cells accumulated in
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