49909
Lanolin
tested according to Ph. Eur.
Synonym(s):
Adeps lanae, Wool fat
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General description
Lanolin is a wool fat. It is a semisolid of high viscosity. Contact allergy to lanolin (wool alcohols), an important sensitizer, in a central London teaching hospital patch-test population has been reported. Simplified extraction of organochlorine and organophosphorus pesticides, frequently found in lanolin, has been proposed. It is utilized as an emulsifier in pharmaceutical and cosmetic formulations.
Application
Lanolin was used to compose the lanolin ointment to estimate the release kinetics of izotretinon and heparin from various semisolid dosage forms by UV-VIS spectroscopy. It was used to prepare the emulsified aqueous solutions containing crystalline dicarboxylic acid. It may be added as excipient to compose a nanoscale-dispersed eye ointment (NDEO) for the treatment of severe evaporative dry eye.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
235.4 °F - closed cup
Flash Point(C)
113 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Oxalic acid as a heterogeneous ice nucleus in the upper troposphere and its indirect aerosol effect.
Zobrist B, et al.
Atmospheric Chemistry and Physics, 6(10), 3115-3129 (2006)
S H Wakelin et al.
The British journal of dermatology, 145(1), 28-31 (2001-07-17)
Lanolin is often stated to be an important sensitizer but some of the available literature is based on the analysis of high-risk patients. To analyse the frequency of contact allergy to lanolin (wool alcohols) in a central London teaching hospital
H Diserens
Journal - Association of Official Analytical Chemists, 72(6), 991-993 (1989-11-01)
In the proposed method, a light petroleum solution of lanolin (wool fat) is adsorbed on diatomaceous earth in an Extrelut column, and the pesticides are eluted with acetonitrile saturated with light petroleum. After evaporation to a small volume, the extract
Flora B de Waard-van der Spek et al.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 26(7), 598-606 (2015-08-20)
Allergic contact dermatitis (ACD) in children appears to be on the increase, and contact sensitization may already begin in infancy. The diagnosis of contact dermatitis requires a careful evaluation of a patient's clinical history, physical examination, and skin testing. Patch
Wenjian Zhang et al.
Nanotechnology, 25(12), 125101-125101 (2014-02-28)
A novel nanoscale-dispersed eye ointment (NDEO) for the treatment of severe evaporative dry eye has been successfully developed. The excipients used as semisolid lipids were petrolatum and lanolin, as used in conventional eye ointment, which were coupled with medium-chain triglycerides
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