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P7003

Supelco

Piperazine hexahydrate

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C4H10N2 · 6H2O
CAS Number:
Molecular Weight:
194.23
Beilstein:
4455527
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

vapor pressure

0.8 mmHg ( 20 °C)

Assay

≥99% (TLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

145-156 °C (lit.)

mp

42-44 °C (lit.)

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].C1CNCCN1

InChI

1S/C4H10N2.6H2O/c1-2-6-4-3-5-1;;;;;;/h5-6H,1-4H2;6*1H2

InChI key

AVRVZRUEXIEGMP-UHFFFAOYSA-N

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General description

Piperazine hexahydrate may be used as a standard for the determination of piperazine in pharmaceutical preparations using colorimetric technique.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Health hazardCorrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Repr. 2 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

190.4 °F - closed cup

Flash Point(C)

88 °C - closed cup


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Colorimetric determination of piperazine in pharmaceutical formulations
Dessouky M Y and Ismaiel A S.
Analyst, 99(1181), 482-486 (1974)
Juneha Bak et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 36(10), 1269-1274 (2020-06-23)
Sulfated saccharides exhibit diverse physiological activities, but a lack of any convenient assay hinders their evaluation. Herein, an assay for the analysis of sulfated saccharides is described using 1H nuclear magnetic resonance (NMR) spectroscopy by employing ligands that can form
William Conway et al.
The journal of physical chemistry. A, 117(5), 806-813 (2013-01-05)
Piperazine (PZ) is widely recognized as a promising solvent for postcombustion capture (PCC) of carbon dioxide (CO(2)). In view of the highly conflicting data describing the kinetic reactions of CO(2)(aq) in piperazine solutions, the present study focuses on the identification
Carl Cheadle et al.
Dalton transactions (Cambridge, England : 2003), 42(14), 4931-4946 (2013-02-07)
A new multidentate bifunctional organic ligand – di-N,N′-(2-cyano-2-oximinoacetyl)piperazine – was synthesized in high yield using a two-step procedure carried out under ambient conditions. At first, the reaction of piperazine and neat methylcyanoacetate led to the di-N,N′-(cyanoacetyl)piperazine (1), which then was
Alejandra Moure et al.
Bioorganic & medicinal chemistry letters, 22(23), 7097-7099 (2012-10-20)
Apoptosis is the process of programmed cell death and plays a fundamental role in several human diseases. We have previously reported the synthesis of the perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives as racemic mixtures. Compounds 1 and 2 showed a potent in

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