70050

Myricetin

≥96.0% (HPLC)

• Synonym(s): 3,3′,4′,5,5′,7-Hexahydroxyflavone, Cannabiscetin, Myricetol
• Empirical Formula (Hill Notation): C₁₅H₁₀O₈
• CAS Number: 529-44-2
• Molecular Weight: 318.24
• Beilstein: 332331
• EC Number: 208-463-2
• MDL number: MFCD00006827
• UNSPSC Code: 12352202
• PubChem Substance ID: 57652239
• NACRES: NA.77

Properties

• Assay: ≥96.0% (HPLC)
• form: powder
• mp: ≥300 °C; >300 °C (lit.)
• solubility: ethanol: 10 mg/mL, clear to very faintly turbid, yellow to very deep greenish-yellow
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• SMILES string: Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3cc(O)c(O)c(O)c3
• InChI: 1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
• InChI key: IKMDFBPHZNJCSN-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544) ; mouse ... Hexa(15211) ; rat ... Il4(287287) , Tnf(24835)

Description

General description

Myricetin (MYR) is a natural polyhydroxyflavonol compound, first isolated from the bark of Morella rubra (Myrica rubra) tree.

Application

Myricetin has been used:

• to study its preventive effect as an antioxidant on noise-induced hearing loss (NIHL) in rats
• as a flavonoid compound to test antiviral activity of Bourbon virus (BRBV) and in inhibition of RNA-dependent RNA polymerase (RdRP)
• to study its effect as a treatment on biofilms of Streptococcus mutans and Candida albicans
• as a reference standard for the quantification of phenolic compounds from Juniperus species

Biochem/physiol Actions

Myricetin exerts anti-oxidant effects, and anti-inflammatory effects by regulating multiple signal pathways. It also displays anti-diabetic and hepatoprotective effects. Myricetin strongly inhibits yeast α-glucosidase, glyoxalase I in vitro, and bovine milk xanthine oxidase. It also promotes complex formation between DNA and both topoisomerase I and II, an effect that may have implications in cancer chemotherapy. Myricetin also has various nutraceuticals values and therapeutic effects.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves