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76275

Sigma-Aldrich

PBFI-AM

suitable for fluorescence, ≥98.0% (HPCE)

Synonym(s):

Potassium indicator PBFI-AM, Potassium-binding benzofuran isophthalate-AM

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About This Item

Empirical Formula (Hill Notation):
C58H62N2O24
CAS Number:
124549-23-1
Molecular Weight:
1171.11
MDL number:
MFCD00083475
UNSPSC Code:
12171500
PubChem Substance ID:
57652631
NACRES:
NA.32

Quality Level

100

Assay

≥98.0% (HPCE)

form

powder

solubility

DMSO: soluble
methanol: soluble

fluorescence

λex 334 nm; λem 525 nm (with Na)
λex 370 nm; λem 540 nm in methanol

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

COc1cc2cc(oc2cc1N3CCOCCOCCN(CCOCCOCC3)c4cc5oc(cc5cc4OC)-c6ccc(cc6C(=O)OCOC(C)=O)C(=O)OCOC(C)=O)-c7ccc(cc7C(=O)OCOC(C)=O)C(=O)OCOC(C)=O

InChI

1S/C58H62N2O24/c1-35(61)75-31-79-55(65)39-7-9-43(45(23-39)57(67)81-33-77-37(3)63)51-25-41-27-53(69-5)47(29-49(41)83-51)59-11-15-71-19-21-73-17-13-60(14-18-74-22-20-72-16-12-59)48-30-50-42(28-54(48)70-6)26-52(84-50)44-10-8-40(56(66)80-32-76-36(2)62)24-46(44)58(68)82-34-78-38(4)64/h7-10,23-30H,11-22,31-34H2,1-6H3

InChI key

AUKRBWNSOWVABU-UHFFFAOYSA-N

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Application

suitable for the detection of K+

Other Notes

Cell permeant deriv. of fluorescent indicator for mitochondrial potassium

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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P. Jezek et al.
The Journal of Biological Chemistry, 264, 10522-10522 (1990)
J P Zoeteweij et al.
The Biochemical journal, 299 ( Pt 2), 539-543 (1994-04-15)
In isolated rat hepatocytes a sustained high increase in intracellular free Ca2+ ([Ca2+]i), induced by extracellular ATP, is associated with mitochondrial dysfunction and cell death. The Ca(2+)-induced effects are Pi-dependent and less severe when the intracellular K+ content is low.
Yu-Chan Wang et al.
Journal of neuroinflammation, 12, 246-246 (2015-12-31)
Acid-sensing ion channels (ASICs) are cation channels which were activated by extracellular acidosis and involved in various physiological and pathological processes in the nervous system. Inflammasome is a key component of the innate immune response in host against harmful and
Yan Li et al.
Reproductive biology and endocrinology : RB&E, 1, 31-31 (2003-05-13)
Ion channels occur as large families of related genes with cell-specific expression patterns. Granulosa cells have been shown to express voltage-gated potassium channels from more than one family. The purpose of this study was to determine the effects of 4-aminopyridine
Dong-Dong Gao et al.
Frontiers in physiology, 9, 1886-1886 (2019-01-23)
As a novel gasotransmitter, hydrogen sulfide (H2S) elicits various physiological actions including smooth muscle relaxation and promotion of transepithelial ion transport. However, the pro-secretory function of H2S in the male reproductive system remains largely unclear. The aim of this study
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