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A9554

Sigma-Aldrich

Allatostatin IV

≥97% (HPLC)

Synonym(s):

Asp-Arg-Leu-Tyr-Ser-Phe-Gly-Leu-NH2

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About This Item

Empirical Formula (Hill Notation):
C45H68N12O12
CAS Number:
123338-13-6
Molecular Weight:
969.09
MDL number:
MFCD00080034
UNSPSC Code:
12352202
PubChem Substance ID:
329771053
NACRES:
NA.26

product name

Allatostatin IV, ≥97% (HPLC)

Assay

≥97% (HPLC)

form

powder

color

white

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(N)=O

InChI

1S/C45H68N12O12/c1-24(2)17-31(38(47)63)52-36(60)22-51-40(65)33(19-26-9-6-5-7-10-26)55-44(69)35(23-58)57-43(68)34(20-27-12-14-28(59)15-13-27)56-42(67)32(18-25(3)4)54-41(66)30(11-8-16-50-45(48)49)53-39(64)29(46)21-37(61)62/h5-7,9-10,12-15,24-25,29-35,58-59H,8,11,16-23,46H2,1-4H3,(H2,47,63)(H,51,65)(H,52,60)(H,53,64)(H,54,66)(H,55,69)(H,56,67)(H,57,68)(H,61,62)(H4,48,49,50)/t29-,30-,31-,32-,33-,34-,35-/m0/s1

InChI key

BYSKWCFHMJZUBY-POFDKVPJSA-N

Amino Acid Sequence

Asp-Arg-Leu-Tyr-Ser-Phe-Gly-Leu-NH2

Biochem/physiol Actions

Allatostatin IV, an octapeptide amine, is a member of the allatoregulatory peptide family found in insects which either inhibit (allatostatins) or stimulate (allatotropins) juvenile hormone (JH) synthesis.
Inhibitor of juvenile hormone synthesis in insects.

Other Notes

Sequence highly conserved within the six C-terminal amino acids.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Zhentao Sheng et al.
Insect biochemistry and molecular biology, 37(1), 90-96 (2006-12-19)
In a previous study, allatotropic and allatostatic activities were observed in brain extract from the Eri silkworm, Samia cynthia ricini (Samcri) [Li, S., Jiang, R.-J., Cao, M.-X., 2002b. Allatotropic and allatostatic activities in brain extracts of the Eri silkworm, S.
Sabine Kreissl et al.
The Journal of comparative neurology, 518(9), 1391-1417 (2010-02-27)
Information transmission and processing in the brain is achieved through a small family of chemical neurotransmitters and neuromodulators and a very large family of neuropeptides. In order to understand neural networks in the brain it will be necessary, therefore, to
N Audsley et al.
Journal of insect physiology, 54(6), 969-980 (2008-04-02)
Allatoregulatory peptides either inhibit (allatostatins) or stimulate (allatotropins) juvenile hormone (JH) synthesis by the corpora allata (CA) of insects. However, these peptides are pleitropic, the regulation of JH biosynthesis is not their only function. There are currently three allatostatin families
Liang Liang et al.
Cell, 181(7), 1680-1692 (2020-06-27)
Metabolism during pregnancy is a dynamic and precisely programmed process, the failure of which can bring devastating consequences to the mother and fetus. To define a high-resolution temporal profile of metabolites during healthy pregnancy, we analyzed the untargeted metabolome of

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