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E2661

Sigma-Aldrich

Estropipate

≥98% (HPLC), powder

Synonym(s):

Estropipate, 3-(Sulfooxy)-estra-1,3,5(10)-trien-17-one : piperazine (1:1), Estrone sulfate piperazine salt, Harmogen, Ogen

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$360.00

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5 MG
$116.00
25 MG
$360.00

About This Item

Empirical Formula (Hill Notation):
C18H22O5S·C4H10N2
CAS Number:
7280-37-7
Molecular Weight:
436.56
EC Number:
230-696-3
MDL number:
MFCD00867399
UNSPSC Code:
51111800
PubChem Substance ID:
329799036
NACRES:
NA.77

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D 100 to 120°, c = 1 in DMSO

color

white to tan

solubility

DMSO: ≥24 mg/mL

originator

Johnson & Johnson

storage temp.

2-8°C

SMILES string

C1CNCCN1.C[C@]23CC[C@H]4[C@@H](CCc5cc(OS(O)(=O)=O)ccc45)[C@@H]2CCC3=O

InChI

1S/C18H22O5S.C4H10N2/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;1-2-6-4-3-5-1/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);5-6H,1-4H2/t14-,15-,16+,18+;/m1./s1

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This Item
1255500SML1405E0251
Estropipate ≥98% (HPLC), powder

E2661

Estropipate

Estropipate United States Pharmacopeia (USP) Reference Standard

1255500

Estropipate

MS37452 ≥98% (HPLC)

SML1405

MS37452

Estrone 3-sulfate sodium salt contains ~35% Tris as stabilizer

E0251

Estrone 3-sulfate sodium salt

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥98% (TLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

-

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: ≥24 mg/mL

solubility

-

solubility

DMSO: 20 mg/mL, clear

solubility

methanol: 19.60-20.40 mg/mL, clear, colorless to faintly yellow

originator

Johnson & Johnson

originator

-

originator

-

originator

-

Biochem/physiol Actions

Estropipate is the piperazine salt of the estrogen receptor agonist estrone-3-sulfate and a potent, specific inhibitor of the organic anion transporting polypeptide 1B1 (OATP1B1, IC50 = 60 nM).
Estropipate is the piperazine salt of the estrogen receptor agonist estrone-3-sulfate and a potent, specific inhibitor of the organic anion transporting polypeptide 1B1.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H302,H350

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1A

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    031M4721V

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