E9750

Estrone

≥99% (HPLC), powder, estrogen receptor agonist

• Synonym(s): 1,3,5(10)-Estratrien-3-ol-17-one, 3-Hydroxy-1,3,5(10)-estratrien-17-one, Folliculin
• Empirical Formula (Hill Notation): C₁₈H₂₂O₂
• CAS Number: 53-16-7
• Molecular Weight: 270.37
• Beilstein/REAXYS Number: 1915077
• EC Number: 200-164-5
• MDL number: MFCD00003620
• UNSPSC Code: 51111800
• PubChem Substance ID: 24278427
• NACRES: NA.77

Properties

• Product Name: Estrone, ≥99%
• biological source: synthetic (organic)
• sterility: non-sterile
• assay: ≥99%
• form: powder
• mp: 258-260 °C (lit.)
• solubility: dioxane: 50 mg/mL, clear, colorless to very faintly yellow
• shipped in: ambient
• storage temp.: room temp
• SMILES string: C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O

Description

General description

Estrone is a weak form of estrogen and exists as estrone sulphate.[1] Estrone is a luteolytic estrogen produced by the corpus luteum.[2] In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase.[3]

Application

Estrone has been used:

• as medium supplement for hormone based degranulation studies of natural killer cells[4]
• as an endocrine disrupting compound for screening bacterial biosensor in toxic water.[5]
• as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines[6]

Biochem/physiol Actions

Estrone is an agonist for the estrogen receptor.[7] The estradiol to estrone interconversion is favourable in menopause.[7] Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone.[8]

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H351,H360FD,H362
• pcodes: P202 - P260 - P263 - P264 - P280 - P308 + P313
• Hazard Classifications: Carc. 2 - Lact. - Repr. 1A
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges