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H8041

Sigma-Aldrich

IL-23 human

HumanKine®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture

Synonym(s):

Human IL-23, IL-23 Cytokine, Interleukin 23

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77

product name

Interleukin-23 human, IL-23, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

biological source

human

Quality Level

100

recombinant

expressed in HEK 293 cells

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

potency

≤2 ng/mL EC50

quality

endotoxin tested

mol wt

dimer 55 kDa (glycosylated)

packaging

pkg of 5X10 μg
pkg of 10 μg
pkg of 5 μg

technique(s)

cell culture | mammalian: suitable

impurities

≤1EU/mg

UniProt accession no.

Q9NPF7

storage temp.

−20°C

Gene Information

human ... IL23A(51561)

General description

HumanKine interleukin-23 (IL-23) is expressed as a heterodimeric 55 kDa cytokine composed of two glycosylated and disulfide linked subunits (p40 cystine linked to p19). Production in human HEK 293 cells offers authentic glycosylation. Cytokines produced in Sf9 or Sf21 cells have post-translational modifications, which are not human-like.

Interleukin-23 (IL-23) is a pro-inflammatory cytokine. It is mostly synthesized by activated dendritic cells and macrophages. It is a 20.7kDa protein with 189 amino acids. IL-23 is mostly expressed on activated/memory T cells and natural killer (NK) cells. This gene is located on human chromosome 12q13.3.

Biochem/physiol Actions

Interleukin-23 (IL-23) plays a major role in cutaneous immune-mediated inflammatory diseases like psoriasis, allergic contact dermatitis and atopic dermatitis. It is involved in cellular immunity, driving the expansion, stabilization and survival of Th17 cells.

Analysis Note

The specific activity was determined by the dose-dependent secretion of h-IFN-γ or IL-8 from human PBMC.

Legal Information

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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IL23A (interleukin 23, alpha subunit p19)
Norimitsu I.
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 15(2) (2011)
Expression of IL-23/Th17-related cytokines in basal cell carcinoma and in the response to medical treatments
Cristina P, et al.
PLoS ONE, 12(8), e0183415-e0183415 (2017)

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