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Key Documents

I4028

Sigma-Aldrich

Monoclonal Anti-Interleukin-18 Receptor antibody produced in mouse

clone 70625.111, purified immunoglobulin, lyophilized powder

Synonym(s):

Anti-IL-18 Receptor

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About This Item

MDL number:
MFCD02096767
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

70625.111, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

flow cytometry: suitable (2.5μg/SUP>106 cell)
immunocytochemistry: 8-25 μg/mL
immunohistochemistry: 8-25 μg/mL

isotype

IgG1

UniProt accession no.

Q13478

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL18R1(8809)

General description

The antibody will neutralize the biological activity of recombinant human IL-18 receptor.

Immunogen

recombinant human IL-18 receptor extracellular domain, expressed in NS0 cells.

Biochem/physiol Actions

IL-18 belongs to the IL-1 cytokine superfamily and is a regulator of innate and acquired immune responses. The immune responses of IL-18 are mediated by its interaction and subsequent signaling by IL-18 receptor complex. The IL-18R complex is made up of α chain that binds to extracellular IL-18 and a β chain that is involved in signal transduction. The IL-18/IL-18R signaling enhances T and NK cell maturation, cytotoxicity and secretion of cytokines.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Preparation Note

Purified using protein G.

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Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J Alastair Gracie et al.
Journal of leukocyte biology, 73(2), 213-224 (2003-01-30)
Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses. IL-18 is expressed at sites of chronic inflammation, in autoimmune diseases, in a variety of cancers
Diana Boraschi et al.
European cytokine network, 17(4), 224-252 (2007-03-14)
IL-18 is among the cytokines responsible for immune-mediated pathologies and is probably one of the factors that contribute to the pathogenesis of autoimmune diseases. Identification of the causes of uncontrolled IL-18 production and activity in autoimmunity would allow for novel

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