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Key Documents

PLA0309

Sigma-Aldrich

Mouse anti-Rictor Monoclonal Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc., clone IG3P2C9

Synonym(s):

AVO3, AVO3 homolog, KIAA1999, MGC39830, PIA, RPTOR independent companion of MTOR, TORC2-specific protein AVO3, complex 2, hAVO3, pianissimo, rapamycin-insensitive companion of mTOR

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

clone

IG3P2C9, monoclonal

species reactivity

human

concentration

1 mg/mL

technique(s)

immunofluorescence: 1:500-1:2,000
immunohistochemistry: 1:100- 1:500
immunoprecipitation (IP): 3 μg/mg
western blot: 1:1,000

isotype

IgG1κ

accession no.

Q6R327

UniProt accession no.

Q6R327

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... RICTOR(253260)

Immunogen

The epitope recognized by PLA0309 maps to a region between residue 1650 and the C-terminus (residue 1708) of human Rapamycin-Insensitive Companion of mTOR using the numbering given in TrEMBL entry Q6R327 (GeneID 253260).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

Rictor (rapamycin insensitive companion of TOR) is part of the rapamycin insensitive mTORC2 complex which includes mTOR, mLST8/GbetaL, Sin1, and protor 1. The mTORC2 complex appears to function in the regulation of cytoskeletal organization and has been shown to phosphorylate Akt/PKB.

Disclaimer

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kaixuan Shi et al.
Cell death and differentiation, 30(1), 195-207 (2022-09-29)
Despite remarkable efficacy, targeted treatments often yield a subpopulation of residual tumor cells in part due to non-genetic adaptions. Previous mechanistic understanding on the emergence of these drug-tolerant persisters (DTPs) has been limited to epigenetic and transcriptional reprogramming. Here, by
Mario Palma et al.
Cell & bioscience, 13(1), 232-232 (2023-12-23)
mTORC2 is a critical regulator of cytoskeleton organization, cell proliferation, and cancer cell survival. Activated mTORC2 induces maximal activation of Akt by phosphorylation of Ser-473, but regulation of Akt activity and signaling crosstalk upon growth factor stimulation are still unclear.

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