PZ0335

CP724714

≥98% (HPLC)

• Synonym(s): (E)-2-Methoxy-N-[3-[4-[[3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl]amino]quinazolin-6-yl]allyl]ethanamide, 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]-acetamide, CP-724,714, CP-724714
• Empirical Formula (Hill Notation): C₂₇H₂₇N₅O₃
• CAS Number: 383432-38-0
• Molecular Weight: 469.53
• MDL number: MFCD15144738
• UNSPSC Code: 12352200
• PubChem Substance ID: 329823846
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: COCC(NC/C=C/C1=CC=C(N=CN=C2NC3=CC=C(OC4=CC=C(C)N=C4)C(C)=C3)C2=C1)=O
• InChI: 1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+
• InChI key: LLVZBTWPGQVVLW-SNAWJCMRSA-N
• Gene Information: human ... ERBB2(2064)

Description

Biochem/physiol Actions

CP724714 is a potent and selective inhibitor of HER2/ErbB2 with an IC₅₀ value of 10 nM. CP724714 is >640-fold selectivity against EGFR, and >1000-fold selective against InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met, JNK-2, JNK-3, ZAP-70, CDK-2 and CDK-5 in in vitro kinase assays. CP724714 had antiproliferative effects in a panel of human breast cancer cell lines.

Other Notes

CP-724714 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the CP-724714 probe summary on the Chemical Probes Portal website.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable