S0447

SIS3

≥98% (HPLC), powder

• Synonym(s): (2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride
• Empirical Formula (Hill Notation): C₂₈H₂₇N₃O₃ · HCl
• CAS Number: 521984-48-5
• Molecular Weight: 489.99
• MDL number: MFCD09265258
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724599
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: yellow
• solubility: H₂O: <2 mg/mL; DMSO: >20 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.COc1cc2CCN(Cc2cc1OC)C(=O)\C=C\c3c(-c4ccccc4)n(C)c5ncccc35
• InChI: 1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;
• InChI key: CDKIEBFIMCSCBB-CALJPSDSSA-N

Description

Application

Sugar insensitive 3 (SIS3) has been used as smad3 inhibitor in various cells.

Biochem/physiol Actions

Sugar insensitive 3 (SIS3) promotes drug-induced apoptosis and hinders the function of adenosine triphosphate (ATP)-binding cassette (ABC) transporter (ABCB1) and ABCG2. It resensitizes ABCB1 and ABCG2 overexpressed in cancerous cells, which contributes to chemotherapeutics.

SIS3 is a novel specific inhibitor of TGF-β1/ALK-5 phosphorylation of Smad3

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves