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Key Documents

SAB2500663

Sigma-Aldrich

Anti-MYB/C-MYB antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-MYB, Anti-Myeloblastosis viral (v-myb) oncogene homolog, avian, Anti-c-Myb_CDS, Anti-v-myb Myeloblastosis viral oncogene homolog (avian)

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About This Item

MDL number:
MFCD01633889
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat, canine

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P10242

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MYB(4602)

General description

Myeloblastosis (MYB) proto-oncogene, transcription factor (MYB) gene codes for a transcriptional activator, Myb-nuclear factor 1 B-type (MYB-NFIB), and is located on human chromosome 6q23.3.

Immunogen

Peptide with sequence C-QRHYNDEDPEKEKR from the internal region of the protein sequence according to NP_005366.2.

Biochem/physiol Actions

Myeloblastosis (MYB) proto-oncogene, transcription factor (MYB) plays a key role in modulating various cellular genes that participates in the proliferation, differentiation, and apoptosis of cells. This protein promotes the development and metastasis of salivary adenoid cystic carcinoma (SACC). MYB plays ah role in initiating and maintaining acute leukemias. It participates in pancreatic cancer, prostate cancer, colorectal cancer, and breast cancer (BC).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Precautionary Statements

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ren-Ming Yang et al.
Oncogene, 38(26), 5239-5249 (2019-04-12)
Over 70% of human breast cancers are estrogen receptor-positive (ER+), most of which express MYB. In these and other cell types, the MYB transcription factor regulates the expression of many genes involved in cell proliferation, differentiation, tumorigenesis, and apoptosis. So
Li-Hua Xu et al.
International journal of oncology, 54(5), 1579-1590 (2019-03-22)
The incidence of recurrent t(6;9) translocation of the MYB proto‑oncogene to NFIB (the gene that encodes nuclear factor 1 B‑type) in adenoid cystic carcinoma (ACC) tumour tissues is high. However, MYB [the gene that encodes transcriptional activator Myb (MYB)] overexpression is more common
Eleni M Rettig et al.
The Laryngoscope, 125(9), E292-E299 (2015-05-13)
Salivary gland adenoid cystic carcinoma (ACC) is rare, aggressive, and challenging to treat. Many ACCs have a t(6;9) chromosomal translocation resulting in a MYB-NFIB fusion gene, but the clinical significance is unclear. The purposes of this study were to describe

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