SAB4200412

Anti-PLAUR/uPAR antibody, Mouse monoclonal

clone PL231, purified from hybridoma cell culture

• Synonym(s): Anti-CD87, Anti-Plasminogen activator urokinase receptor, Anti-UPAR, Anti-URKR, Monoclonal Anti-PLAUR/uPAR antibody produced in mouse
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified from hybridoma cell culture
• antibody product type: primary antibodies
• clone: PL231, monoclonal
• form: buffered aqueous solution
• mol wt: antigen ~55 kDa
• species reactivity: monkey, rat, canine, human, mouse
• enhanced validation: recombinant expression; Learn more about Antibody Enhanced Validation
• concentration: ~1.0 mg/mL
• technique(s): indirect immunofluorescence: suitable; western blot: 4.0-8.0 μg/mL using extracts of HL-60 cells
• isotype: IgG1
• UniProt accession no.: Q03405
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... PLAUR(5329)

Description

General description

Plasminogen activator, urokinase receptor (PLAUR) is a well-characterized receptor for matrix-degrading proteases. It is encoded by the gene mapped to human chromosome 19q13.31.

Immunogen

peptide corresponding to a sequence at the C-terminus of human PLAUR/uPAR.

Application

Monoclonal Anti-PLAUR/uPAR antibody produced in mouse has been used in Western blotting (WB).

Biochem/physiol Actions

Plasminogen activator, urokinase receptor (PLAUR) plays a vital role in tumor cell invasion, angiogenesis and metastasis. It acts as a key regulator of cell-surface plasminogen activator. It is implicated in various normal and pathological processes. Elevated expression of the gene has been observed in various types of cancers, including head and neck squamous cell carcinoma (HNSCC). Thus, it is considered as an potent biomarker for targeted imaging or therapy. Upregulated expression of PLAUR leads to the progression of kidney disease in children.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable