SAB4700394

Monoclonal Anti-CD29 antibody produced in mouse

clone MEM-101A, purified immunoglobulin, buffered aqueous solution

• Synonym(s): Anti-ITGB1, Anti-Integrin β1 chain
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: MEM-101A, monoclonal
• form: buffered aqueous solution
• species reactivity: human, pig, canine
• concentration: 1 mg/mL
• technique(s): flow cytometry: suitable
• isotype: IgG1
• NCBI accession no.: NM_002211.3
• UniProt accession no.: P05556
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... ITGB1(3688)

Description

General description

Cluster of differentiation 29 (CD29), also known as integrin subunit β 1 (ITGB1), is a mechanosensor, encoded by the gene mapped to human chromosome 10p11.22. It is present in both normal cells and tumor-associated cells. The encoded protein has ubiquitous expression with a molecular mass of 130kDa.

The antibody MEM-101A reacts with CD29 (integrin beta1 chain), a 130 kDa single chain type I glycoprotein expressed as a heterodimer (non-covalently associated with the integrin alpha subunits 1-6). CD29 is broadly expressed on majority of hematopoietic and non-hematopoietic cells (leukocytes, platelets, fibroblasts, endothelial cells, epithelial cells and mast cells).

Immunogen

Raji Burkitt′s lymphoma cell line

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Flow cytometry/Cell sorting (1 paper)

Biochem/physiol Actions

Cluster of differentiation 29 (CD29) acts as an adhesive molecule in the development of de novo focal contact, keratinocyte migration and re-epithelialization of wound tissue. CD29 with/without CD27 induce apoptosis, in association with a multifunctional protein galectin (Gal)-3.

Features and Benefits

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Physical form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable