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Key Documents

SAB5600114

Sigma-Aldrich

Anti-CD140b (PDGF Receptor beta)antibody, Rabbit Monoclonal

recombinant, expressed in HEK 293 cells, clone RM303, purified immunoglobulin

Synonym(s):

Platelet-derived growth factor receptor beta

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

recombinant

expressed in HEK 293 cells

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

RM303, monoclonal
recombinant monoclonal

form

buffered aqueous glycerol solution

species reactivity

human

technique(s)

immunohistochemistry: 1:500-1:1000
western blot: 1:250-1:500

isotype

IgG

NCBI accession no.

5159

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PDGFRB(5159)

General description

The PDGFRB (platelet derived growth factor receptor β) gene is mapped to human chromosome 5q32. It encodes for a receptor tyrosine kinase.

Specificity

This antibody reacts to human CD140b (PDGFR-beta) (Platelet-derived growth factor receptor beta).

Immunogen

A peptide corresponding to the C-terminus of human CD140b.

Biochem/physiol Actions

PDGFRB (platelet derived growth factor receptor β) acts as a regulator of mesenchymal cells in tumour cells. Upregulation of the gene is observed in gastric cancer, breast and prostate cancers. Mutations in the gene is associated with infantile myofibromatosis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer.
Staub E, et al.
Molecular Cancer, 5(1), 37-37 (2006)
Quantitative proteomic analysis of gastric cancer tissue reveals novel proteins in platelet-derived growth factor b signaling pathway.
Liu F
Oncotarget, 8(13), 22059-22075 (2017)
PDGFRB gain-of-function mutations in sporadic infantile myofibromatosis.
Arts FA
Human Molecular Genetics, 26(10), 1801-1810 (2017)

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