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Key Documents

SCP0204

Sigma-Aldrich

Orexin B human

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About This Item

Empirical Formula (Hill Notation):
C123H212N44O35S1
Molecular Weight:
2899.34
UNSPSC Code:
12352200
NACRES:
NA.32

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥72%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

General description

Orexin B consists of an amidated C-terminus and shares 46% sequence identity with orexin-A, mainly in the C-terminal region. Orexin-B is proteolytically cleaved from the precursor prepro-orexin.

Biochem/physiol Actions

Orexin-A and Orexin-B are orexigenic peptides that mediate their effects via two receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexins are involved in food intake, obesity regulation, energy homeostasis, and differentiation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J E Digby et al.
The Journal of endocrinology, 191(1), 129-136 (2006-10-27)
Orexin-A and orexin-B, via their receptors orexin-1 receptor (OX1R) and orexin-2 receptor (OX2R) have been shown to play a role in the regulation of feeding, body weight, and energy expenditure. Adipose tissue also contributes significantly to the maintenance of body
Manja Lang et al.
Journal of medicinal chemistry, 47(5), 1153-1160 (2004-02-20)
The neuropeptides orexin A and B (also known as hypocretins) play an important role in many physiological and behavioral activities. Orexins are ligands of two closely related G-protein-coupled receptors, that are the named orexin 1 and orexin 2 receptors. To
Masayuki Ikeda et al.
PloS one, 4(11), e7737-e7737 (2009-11-10)
THE SLEEP SEQUENCE: i) non-REM sleep, ii) REM sleep, and iii) wakefulness, is stable and widely preserved in mammals, but the underlying mechanisms are unknown. It has been shown that this sequence is disrupted by sudden REM sleep onset during

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